The Spice Isles are a chain of islands on Dominaria. They are located to the west of the continent of Aerona, and are made up of sparsely populated islands stretching to far Terisiare. Throughout the years they have been used by sailors as rest stops on the long ocean voyage between the continents.
The Spice Isles were ruled by pirates before they were conquered by the Sheoltun Empire. Later, Benalia assumed control over them. During the Time Spiral crisis, the Spice Isles became the home of Tolaria West. Benalia lost its hold during the Rift Era, but reestablished itself in the Mending Era.
Within the present-day Spice Isles, a safe haven for planeswalkers exists called Sanctum. It is shielded from external threats by Thran metal.